Which SSRI is generally considered the safest option during pregnancy and breastfeeding?

Sertraline is generally considered the safest option during pregnancy and breastfeeding due to its favorable safety profile compared to other SSRIs. Research indicates that sertraline has a lower risk of adverse effects on the fetus or newborn when used during pregnancy, particularly in comparison to medications like paroxetine, which has been associated with an increased risk of congenital malformations.

Additionally, sertraline is excreted into breast milk in lower concentrations than some other antidepressants, making it a preferred choice for nursing mothers. Its effectiveness in managing depression and anxiety disorders, along with a relatively benign side effect profile, supports its recommendation for use in these populations. This combination of safety in pregnancy and minimal risk during breastfeeding underscores the rationale for selecting sertraline over the other listed medications.