Which of the following is a drug interaction with MAOIs?

The interaction of interest here is between MAOIs (Monoamine Oxidase Inhibitors) and dextromethorphan, which is a common cough suppressant found in various over-the-counter medications. When used in conjunction with MAOIs, dextromethorphan can lead to serious side effects, including the risk of serotonin syndrome. This syndrome occurs when there is an excess of serotonin in the brain, which can lead to symptoms such as confusion, agitation, rapid heart rate, and high blood pressure.

MAOIs work by inhibiting the enzyme monoamine oxidase, which is responsible for breaking down neurotransmitters such as serotonin, norepinephrine, and dopamine. When dextromethorphan is taken with an MAOI, it can also increase serotonin levels, leading to an elevated risk for serotonin syndrome.

On the other hand, ibuprofen, paracetamol (acetaminophen), and alprazolam do not have the same interactions with MAOIs. Ibuprofen and paracetamol are analgesics and antipyretics commonly used to relieve pain and reduce fever, and they do not influence serotonin levels. Alprazolam, which is a benzodiazepine typically used to treat anxiety and