Which condition is a potential risk with long-term use of Valproic Acid?

Long-term use of Valproic Acid, a medication commonly used to treat epilepsy and bipolar disorder, is associated with several risks, one of the most significant being liver failure. Valproic Acid can lead to hepatotoxicity, as it has been shown to affect liver function adversely, especially in patients with pre-existing liver conditions, young children, and those on concomitant medications that also stress the liver. Regular monitoring of liver enzymes is essential during treatment to catch any potential signs of liver distress early on.

While the other options may present other health concerns, they are not the primary risks linked to Valproic Acid in the same way liver failure is. For instance, some medications can influence bone density over time, and there are growing concerns about metabolic effects including diabetes, but liver failure remains the most serious direct risk associated with this drug.