When should patients be cautioned about the use of Lamotrigine?

Cautioning patients about the use of Lamotrigine is particularly important due to the risk of developing a rash. This medication can lead to severe skin reactions, including Stevens-Johnson syndrome, which can be life-threatening. Therefore, it is vital for patients to be monitored for any signs of rash, especially during the initial stages of treatment or when the dosage is increased. Informing patients about this risk enables them to be vigilant and seek medical attention should they notice any skin changes, thereby preventing serious complications.

The other options, while they may pose their own considerations, do not encompass the critical urgency associated with the risk of rash that comes with Lamotrigine use. Educating patients about the potential for serious skin reactions is a primary concern and is essential for ensuring their safety while on this medication.