What is the major active metabolite of Venlafaxine?

Desvenlafaxine is the major active metabolite of Venlafaxine. When Venlafaxine is metabolized in the body, it is converted into Desvenlafaxine, which is itself an active compound. This metabolite retains similar pharmacological properties, primarily functioning as a serotonin-norepinephrine reuptake inhibitor (SNRI), which contributes to its therapeutic effects in the treatment of major depressive disorder and anxiety disorders.

Understanding this metabolic pathway is crucial in pharmacology and psychiatry, as it helps inform dosing, efficacy, and potential side effects associated with Venlafaxine treatment. Desvenlafaxine's activity in the body is significant enough that it is also marketed as a separate medication, which underscores the importance of recognizing it as the primary active substance arising from Venlafaxine metabolism.