What is one of the additional uses of Imipramine beyond depression?

Imipramine, primarily used as an antidepressant in the tricyclic category, has established efficacy in treating additional conditions beyond major depressive disorder. One notable use is in the treatment of nighttime bed-wetting, also known as nocturnal enuresis, particularly in children. The medication works by acting on neurotransmitters in the brain that can help reduce bladder contractions, thereby assisting in controlling urination during sleep.

In contrast, while imipramine may possess some properties that can be beneficial for chronic pain, insomnia, and anxiety disorders, these are not its primary or most well-supported uses. Chronic pain may be managed with various medications, but tricyclics like imipramine are not specifically the first line for that purpose. Similarly, there are other medications more commonly prescribed for insomnia and anxiety that do not include imipramine as a primary treatment option. Thus, the role of imipramine in addressing nighttime bed-wetting is a definitive and recognized alternative use of this medication.