Does Vilazodone typically cause weight gain as a side effect?

Vilazodone is commonly prescribed for the treatment of major depressive disorder and is classified as a serotonin reuptake inhibitor with additional partial agonist activity at the 5-HT1A receptor. One of the notable aspects of Vilazodone is its weight-neutral profile, meaning that it does not typically lead to significant weight gain in patients. Many clinical studies and patient reports suggest that rather than causing weight gain, Vilazodone does not impact weight or may even be associated with weight loss in some individuals.

This distinguishing characteristic sets Vilazodone apart from other antidepressants that are known to contribute to weight gain as a side effect. Its mechanism of action affects serotonin levels without a substantial impact on appetite or metabolism, which is often the cause of weight changes associated with other medications.

When considering the overall effects of various antidepressants, weight gain can be a considerable concern for patients, leading them to select medications that will not exacerbate this issue. This aspect of Vilazodone makes it a preferred choice for patients who are concerned about weight change during their treatment for depression.